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Melt Pump for Drug Hot Melt Extrusion

 Melt pump drug hot melt extrusion (HME), as a new drug delivery technology, creatively combines processing technology with pharmacy to carry out drug delivery research. It aims to improve the solubility and bioavailability of insoluble APIs, develop new sustained and controlled release preparations, and prepare masking pellets or other special shaped preparations, such as implants, with broad application prospects. It combines many advantages of solid dispersion technology and mechanical preparation, realizes dust-free, continuous operation, good reproducibility, and extremely high production efficiency.

Thermo Scientific Pharma Twin Screw Extruder Series belongs to continuous process instrument in essence. It supports modern pharmaceutical science to create new solid drug dosage forms by adopting four technological modes: melt pump drug hot melt extrusion, melt pump melt granulation, dry granulation, wet granulation and wet extrusion. It can create new solid drug dosage forms and realize five processes through one equipment. The mode is used alternately. APIs and excipient concentration were simultaneously detected by near infrared (NIR) spectroscopy in real time. As a tool of process analysis technology (PAT) and quality derived from design principles (Qbd), the process and real-time process control were further understood.

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